WASHINGTON—President-elect Joe Biden’s ambitious Democratic agenda—including raising corporate taxes—faces formidable opposition from a power center he knows well: former aides who are now lobbyists or advisers to companies and industries at odds with his goals.

Scores of Mr. Biden’s former aides now on K Street represent hundreds of companies, trade groups and foreign companies. One person in the mix for a top White House role is Mr. Biden’s campaign chairman Steve Ricchetti, who co-owned a lobbying firm for more than a decade…

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